According to a new practice guideline from the American College of Physicians (ACP), second-generation antidepressants are equally effective for treatment of depression in adults.
Second-generation antidepressants include:
- Celexa (citalopram)
- Cymbalta (duloxetine)
- Desyrel (trazodone)
- Effexor (venlafaxine)
- Lexapro (escitalopram)
- Luvox (fluvoxamine)
- Prozac (fluoxetine)
- Paxil (paroxetine)
- Remeron (mirtazapine)
- Serzone (nefazodone)
- Wellbutrin (bupropion)
- Zoloft (sertraline)
In a news release from the ACP, the lead author of the guidelines said that "The studies we analyzed show that second generation drugs have different adverse effects but are equally effective for treating depression.”
The guidelines recommend that, “When drugs are used to treat depression, doctors and patients should select a second-generation antidepressant on the basis of side effect profiles, cost, and patient preferences.”
Members of the American College of Physicians are internists, who are specialists in the care of adults.
The guidelines, published in November, can be viewed at: Using Second-Generation Antidepressants to Treat Depressive Disorders: A Clinical Practice Guideline from the American College of Physicians.
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